Vol. 8, Issue 4, Part A (2025)
Utility of Core Needle Biopsy (CNB) in diagnosis of breast lesions
Darshni Kotecha, Hemina H Desai, Zankruti B Mehta, Jemisha V Aghera, Unnati P Patel and Dishang R Bhavsar
Background: Breast cancer is the most common malignancy affecting Indian women. Accurate diagnosis is crucial for effective management and improved outcomes. Core needle biopsy (CNB) is a reliable and safe method for diagnosing breast lesions. This study evaluates the diagnostic accuracy of CNB in detecting breast lesions.
Methods: A study was conducted on 50 patients who had undergone CNB of breast lumps at BJ Medical College, Civil Hospital, Ahmedabad, Gujrat, India. Biopsies were processed by paraffin method and H&E stained sections were prepared. CNB results were categorized into B1 to B5 categories according to UK NCCBSP.
Results: Among 50 cases, 10 had normal breast tissue (B1), 14 were benign (B2) and 16 were malignant (B5). 8 cases had lesions with uncertain malignant potential (B3) and 2 cases fell in suspicious for malignancy (B4) category. No CNBs were inadequate for reporting. Out of the 10 B1 cases, surgical follow-up was deferred in 9 patients. Out of the 8 B3 cases, 2 patients were lost to follow up.
Mastitis was the most common benign lesion and invasive ductal carcinoma, no special type was the most common malignant lesion.
CNB showed 88.8%, sensitivity, 100% specificity, 100% positive predictive value (PPV) and 80% negative predictive value (NPV). Diagnostic accuracy was 92.3%.
Conclusion: Core needle biopsy (CNB) is an effective initial investigation for the pre-operative diagnosis of breast lesions. It has good patient compliance, can be performed in outpatient settings, and helps reduce overall costs. CNB allows for accurate histopathological diagnosis of malignant lesions.Darshni Kotecha
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