Vol. 8, Issue 1, Part A (2025)

Study was conducted to estimation efficiency of alcoholic Leaves extract from Melissa officinalis in treatment of induced hypothyroidism in male albino rats. The aim of this study was to investigate the effects of oral administration of Melissa officinalis leaves extract on biomarkers of Thyroid hormones and lipid profile in induced hypothyroidism rats. Fifty male rats were divided into five groups, ten for each one. Group I selected as negative control and administered orally with normal saline alone, group II served as positive control and treated by carbimazole (5 mg/kg) anti-thyroid drug for six weeks. Group Ⅲ treated by carbimazole to induce hypothyroidism, then treated by plant extract (75 mg/day). Group Ⅳ treated by carbimazole to induce hypothyroidism, then treated by plant extract (150 mg/day) And the group V was treated by carbimazole (5 mg/kg), then treated by thyroxin (50 µg). The results showed non-significant differences in T₃ and T₄ level in third, fourth and fifth groups when compared with the first group, while the results showed a significant increase (p≤0.05) when compared with second group. Results showed insignificant differences in the level of TSH in the third, fourth and fifth groups when compared with the first, while there was a significant decrease when compared with the second group. The results showed an insignificant differences in the concentrations of TG, TC, LDL-c, and VLDL-c in the third, fourth and fifth groups when compared with the first group, while there was a significant decrease when compared with the second group. Also, the results showed an insignificant differences in the concentrations of LDL-c in third, fourth group and fifth groups when compared with the first group, while there was a significant decrease when compared with the second group. In conclusion, Melissa officinalis leaves extract succeeded in amelioration of thyroid function towards normal level. Melissa officinalis have efficacy in improves lipid profile regulation inside the body.