Vol. 8, Issue 1, Part A (2025)

Background: Bone lesions are less commonly encountered lesions, and they pose a definitive diagnostic challenge. A spectrum of pathological bone lesions can be presented in any form from inflammatory to neoplastic conditions. Diagnosis of all bone lesions is made by radiological modalities like plain X-ray, CT scan, MRI and bone scintigraphy. Histopathological examination of these lesions is important to identify the morphological features and make a diagnosis. 
Aim and Objectives: To study histopathological features of bone lesions and correlate them with age, site and type of lesions.
Material and Methods: The study was carried out at tertiary care hospital from August 2022 to June 2024. A total of 93 bone lesions were analyzed. Bone biopsy was performed after detailed clinical and radiological examination. After fixation, decalcification, processing and H & E staining, histopathological diagnosis was made.
Results: Out of 93 cases, 42.4% bone lesions were found in <25 years with male predominance. The incidence of non-neoplastic lesions was 72.04% and neoplastic lesions was 27.95%. Amongst neoplastic lesions, incidence of benign tumors was 22.54% and malignant lesions was 5.40%. Chronic osteomyelitis was most common cause of non-neoplastic lesions, while giant cell tumor was most common cause for benign neoplastic lesions and osteosarcoma and chondrosarcoma were most common cause of malignant bone lesions.
Conclusion: Though bone tumors are less common, if viewed in perspective of clinic-radiology and histopathology, correct diagnosis can be made.