Vol. 7, Issue 3, Part E (2024)

Background: type 1 Diabetes Mellitus (T1DM) is an autoimmune disease that leads to the destruction of insulin-producing pancreatic beta cells. T1DM patients typically present with hyperglycemic symptoms such as polyuria, polydipsia, polyphagia, nocturnal enuresis, blurred vision, and weight loss. The study aimed to investigate the association between bone resorption (CTX) and bone formation (PINP) markers in T1DM patients.

Methods: This cross-sectional case-control study was conducted at Al Faiha Diabetes, Endocrine, and Metabolism Center in Basrah, Iraq, from July 1 to November 7, 2023. A total of 200 participants were included: 100 diagnosed with T1DM and 100 matched healthy controls from Basrah's general population. The study aimed to investigate the association between bone resorption markers (CTX) and bone formation markers (PINP) in T1DM patients.

Results: The majority (63%) of T1DM patients were under 15 years old, with 50% being underweight. About 58% of patients had diabetes for ≤5 years, 91% had HbA1c levels ≥8.5%, and 24% experienced complications such as diabetic ketoacidosis (DKA). Biochemical analysis revealed that 48% of T1DM patients had elevated CTX levels compared to controls, while only 13% had low PINP levels. A significant association was found between CTX and PINP levels with age and BMI (P-value < 0.05).

 Conclusion: T1DM patients had higher serum CTX levels than controls, but this difference was not statistically significant. Similarly, controls had higher PINP levels than T1DM patients, though the difference was not statistically significant.