Vol. 7, Issue 3, Part C (2024)
Correlation of serum PSA level with histopathological findings of prostate specimens in tertiary care hospital
Author(s):
Dr. Keta Patel, Dr. Hetal Jani and Dr. Hansa Goswami
Abstract:
Introduction: Prostate cancer is the most common malignancy in men over 65 years of age. PSA is a glycoprotein produced by epithelial cells of prostatic tissue with normal levels of 0-4ng/ml. Increased PSA levels are seen in all prostatic diseases but markedly elevated levels are seen in carcinoma prostate.
Aims and objectives
• To establish the correlation of histopathological findings with serum prostate specific antigen levels.
• To evaluate the histopathological spectrum of non- neoplastic and neoplastic lesions of prostate in correlation of serum PSA level.
Methodology: Retrospective study of 120 patients was done in department of pathology, civil hospital, Ahmedabad from 1/10/23 to 30/6/24. Unwilling, inadequate biopsies, metastatic carcinoma and severely morbid patients were excluded.
Results: Benign prostatic hyperplasia was the most common lesion with 44.1% followed by carcinoma with 35%. Serum prostate specific antigen level was increased in 76.7% cases.
Conclusion: The serum prostate specific antigen levels are a good indicator for the glandular proliferation of prostate. It is a highly sensitive tumor marker with a low specificity as many benign conditions also increase its level. Serum PSA is an early marker for prostate cancer but a more specific test is needed for screening.
Pages: 159-163 | 125 Views 41 Downloads
How to cite this article:
Dr. Keta Patel, Dr. Hetal Jani and Dr. Hansa Goswami. Correlation of serum PSA level with histopathological findings of prostate specimens in tertiary care hospital. Int. J. Clin. Diagn. Pathol. 2024;7(3):159-163. DOI: 10.33545/pathol.2024.v7.i3c.596
