Introduction and objective: Many strains of Papillomavirus are well known to be associated with cervical neoplasia, and thus it is expected that some precancerous cervical cytological changes may be present in Papillomavirus-positive cases where florid precancerous dysplastic changes may be completely absent.
Methodology: In this pilot study, we had selected five Papilloma virus DNA positive cases by Real time PCR; where there was no classical cytological precancerous changes were observed and compared their morphological parameters with five Papilloma virus DNA negative cases, to find out some minor morphometric parameters that may be significantly different in positive cases.
Results: Our findings indicated that some cytological parameters are constantly present in all HPV DNA positive cases. Those including irregular nuclear membranes, anisochromasia, vesiculation, and significantly fewer degenerative cells. Although not so significant, some other parameters may also be associated with positive cases: Increased cellular thickness, mildly decreased nuclear: cytoplasmic ratio, and increased cell population.
Conclusion: Thus, these initial cytological changes may be of some value in identification of the abnormal activities of the Papillomavirus in early cervical infections.
