Introduction: Spindle cells are of mesenchymal origin and part of connective tissue. Soft tissues defined as non-epithelial, extra skeletal tissues of the body that may be voluntary muscles, fat and fibrous tissue and vessels. Soft tissue tumours are defined as mesenchymal proliferation which occur in the extraskeletal nonepithelial tissues of the body, excluding the viscera, coverings of brain and lymphoreticular system.
Aims: The aims of the study is to classify according to WHO, evaluate the incidence rate and age, sex, site wise distribution and histopathological findings of the various types of spindle cell soft tissue tumours and comparing it with national and international study.
Materials and Methods: The present study was done on surgical specimens received in Department of Pathology from August 2019 to August 2021. The Autolysed, poorly preserved specimens were excluded from the study. The specimens were fixed, grossly examined, representative tissue bits taken, processed in automated tissue processor for routine paraffin embedding, Tissue sectioning by microtomy and staining with the routine hematoxylin and eosin method done. Special stains were used if necessary. The microscopic examination was done and the results were analysed.
Results: Out of 110 cases of spindle cell soft tissue tumors, most common tumors were Peripheral nerve sheath tumours (34.5%) followed by Fibroblastic and myofibroblastic tumours (22.7%). Most of the cases in present study occur between 21-30 years of age and more common in males. Higher rates of tumours located in head and neck region (36.4%).
Conclusion: Spindle cell soft tissue tumours are classified according to morphological and histogenetic basis. Definite diagnosis especially for difficult cases should be made by performing immunohistochemistry and molecular biology. Present study was unique on the basis of that it includes spindle cell soft tissue tumours.