International Journal of Clinical and Diagnostic Pathology

Background: To diagnose various histological types of papillary lesions of the breast according to the newer WHO classification and to study the expression of myoepithelial cell marker p63 in various papillary lesions.

Material and Methods: The study was done on 21 patients with breast lesions between Jan 2015 to June 2016. Breast biopsies (incisional as well as excisional) were retrieved from the histopathology section of the department.

Result: P63 showed a nuclear positivity in myoepithelial cells. It was retained in the benign papillary lesions with some exceptions and was almost completely lost in malignant papillary neoplasms Conclusion: P63 can be used to observe the characteristic pattern of nuclear staining and delineate the myoepithelial layer wherever needed.