International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology

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Vol. 5 Issue 1 Part A

2022, Vol. 5 Issue 1, Part APages: 35-38

Plasma endothelin-1 role on initial atherosclerotic lesion formation in young obese wistar rats: An experimental study

Muhammad Isman Sandira, Irfan Idris, Muhammad Husni Cangara, Muhammad Aryadi Arsyad and Itzar Chaidir Islam
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ABSTRACT
Background: Obesity has a strong relationship with the acceleration of initial atherosclerosis lesion formation that marked by increasing of some biomarkers such as endothelin-1 (ET-1). Obesity also becomes a risk factor for the emergence of various metabolic diseases like hypertension and type 2-diabetes. This study aims to reveal the relation of endothelin-1 serum levels with the early lesion of atherosclerosis.
Results: There were an increasing value in serum ET-1 level and aorta foam cells count in obese group compared to normal group. Furthermore, there is a strong positive correlation between serum ET-1 level and the amount of aorta foam cells (r = 0.628) in young obese rats.
Conclusions: ET-1 showed an important role to triggering the emergence of early lesions in of atherosclerosis in young age obese rat.
How to cite this article:
Muhammad Isman Sandira, Irfan Idris, Muhammad Husni Cangara, Muhammad Aryadi Arsyad, Itzar Chaidir Islam. Plasma endothelin-1 role on initial atherosclerotic lesion formation in young obese wistar rats: An experimental study. Int J Clin Diagn Pathol 2022;5(1):35-38. DOI: 10.33545/pathol.2022.v5.i1a.452
International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology
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