Vol. 5, Issue 1, Part A (2022)
Plasma endothelin-1 role on initial atherosclerotic lesion formation in young obese wistar rats: An experimental study
Author(s):
Muhammad Isman Sandira, Irfan Idris, Muhammad Husni Cangara, Muhammad Aryadi Arsyad and Itzar Chaidir Islam
Abstract:
Background: Obesity has a strong relationship with the acceleration of initial atherosclerosis lesion formation that marked by increasing of some biomarkers such as endothelin-1 (ET-1). Obesity also becomes a risk factor for the emergence of various metabolic diseases like hypertension and type 2-diabetes. This study aims to reveal the relation of endothelin-1 serum levels with the early lesion of atherosclerosis.
Results: There were an increasing value in serum ET-1 level and aorta foam cells count in obese group compared to normal group. Furthermore, there is a strong positive correlation between serum ET-1 level and the amount of aorta foam cells (r = 0.628) in young obese rats.
Conclusions: ET-1 showed an important role to triggering the emergence of early lesions in of atherosclerosis in young age obese rat.
Pages: 35-38 | 856 Views 277 Downloads
How to cite this article:
Muhammad Isman Sandira, Irfan Idris, Muhammad Husni Cangara, Muhammad Aryadi Arsyad and Itzar Chaidir Islam. Plasma endothelin-1 role on initial atherosclerotic lesion formation in young obese wistar rats: An experimental study. Int. J. Clin. Diagn. Pathol. 2022;5(1):35-38. DOI: 10.33545/pathol.2022.v5.i1a.452
