Prevalence of Weak D (Du) among blood donors in South-West region of Maharashtra- An Observational study

Suchita V Deshmukh; Sunita B Patil; Rashmi Metri; Trupti K Gade; Vinayak J Deshmukh

doi:10.33545/pathol.2021.v4.i1c.341

Prevalence of Weak D (Du) among blood donors in South-West region of Maharashtra- An Observational study

Suchita V Deshmukh, Sunita B Patil, Rashmi Metri, Trupti K Gade and Vinayak J Deshmukh

DOI: https://doi.org/10.33545/pathol.2021.v4.i1c.341

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ABSTRACT

Background: ABO was the first blood group system to be discovered by Landsteiner in 1901 and then along with Weiner he discovered Rh antigen in 1939 which farther led to description of haemolytic disease of new born by Levine and Stetson. The term Rh positive and Rh negative refers to the presence or absence of D antigen. The incidence of Rh negativity varies between 3%-25% and that of the weak D antigen range from 0.2-1%. This study aimed to find the prevalence of Weak D among blood donors.

Materials and methods: ABO and Rh Blood Group of donors was analysed in our blood bank from 2018 to 2020 in South West region of Maharashtra, India. Rh negative individuals were further processed for detection of weak “D” antigen by gel card method using LISS/Coombs reagent.

Results: A total of 21823 blood samples were analysed during the period 2018 to 2020. Out of these 20746 (95.06%) were Rh D positive and 1077 (4.93%) were Rh D negative. Out of 1077 Rh negative blood samples 45 (4.1%) were found positive for weak D antigen.

Conclusion: The prevalence of Rh-negative blood group is 4.93% and weak D positive is 4.1% among the blood donors of south west region of Maharashtra.

International Journal of Clinical and Diagnostic Pathology

Vol. 4 Issue 1 Part C

Prevalence of Weak D (Du) among blood donors in South-West region of Maharashtra- An Observational study

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