Estrogen and progesterone receptor expression and blood vessel density in abnormal uterine bleeding

Material and method: The present study was conducted in the department of Pathology at SMS Medical College, Jaipur among specimens received from 266 patients presenting with abnormal uterine bleeding in reproductive age group (18-45 years) on endometrial biopsies and hysterectomy specimens. The intensity and distribution of ER, PR was evaluated using a semi-quantitative method Allred score. Also density of blood vessels /10 HPF was evaluated.

Results: Neoplastic cases were found among 9.4% (25) of the subjects whereas non-neoplastic lesions were present in 90.6% (241) of the subjects. Mean Allred scoring of estrogen and progesterone receptor in glandular component was highest among endometrial carcinoma. Mean Allred scoring of estrogen receptor in stromal component was highest among Hyperplasia without atypia (5.13±1.58). Mean progesterone receptor in stroma component was highest among Hyperplasia without atypia followed by disordered maturation and endometrial carcinoma.

Conclusion: The results of the present study showed that ER and PR expression are useful investigations. There expression varies in various causes of abnormal bleeding. Future studies with clinical trials could be done to try medical treatment of AUB.