Study to know the utility of HBME 1 and CK 19 in thyroid neoplasm: A tertiary care hospital and study

Dr. Ramya Gandhi; Dr. Erli Amel Ivan; Dr. Vigneswaramoorthi V; Dr. Sriram

doi:10.33545/pathol.2021.v4.i1a.316

Study to know the utility of HBME 1 and CK 19 in thyroid neoplasm: A tertiary care hospital and study

Dr. Ramya Gandhi, Dr. Erli Amel Ivan, Dr. Vigneswaramoorthi V and Dr. Sriram

DOI: https://doi.org/10.33545/pathol.2021.v4.i1a.316

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ABSTRACT

Introduction: Thyroid tumors are the most common endocrine tumors. Thyroid cancer is four times more common in women when compare to men. In the differentiation of thyroid lesions, cytokeratin 19 (CK19) and Hector Battifora mesothelial–1 (HBME -1) expressions were examined in many studies and significant results were obtained. In normal thyroid, follicular epithelium shows absence Cytokeratin 19 expression. Many studies reported a strong and diffuse staining pattern of CK19 in PTC. Expression of Hector Battifora mesothelial–1 was demonstrated in malignant thyroid neoplasms, especially PTCs.

Aims: To study the cytological and histomorphological features of thyroid neoplasm; and to analysis the utility of thyroid neoplasm; and to analysis the utility of immunohistochemical staining – HBME1 and CK-19 in thyroid neoplasm.

Results: A total of 29 patients with thyroid neoplasm were surgically operated and specimen were reviewed. Out of which 23 (79.4%) were females and 6 (20.6%) were males. Age of the patients ranged from 16 to 66 years. Expression of CK-19 in PTC seen in 15 (93.75%) cases in that 14 cases showed strong and diffuse positivity and 1 cases showed weak and focal positivity. Expression of CK-19 in FC is absent.

Conclusion: Thyroid neoplasm, cytological, histomorphological features immunohistochemical staining, HBME -1, CK- 19.