International Journal of Clinical and Diagnostic Pathology

Introduction: Thyroid tumors are the most common endocrine tumors. Thyroid cancer is four times more common in women when compare to men. In the differentiation of thyroid lesions, cytokeratin 19 (CK19) and Hector Battifora mesothelial–1 (HBME -1) expressions were examined in many studies and significant results were obtained. In normal thyroid, follicular epithelium shows absence Cytokeratin 19 expression. Many studies reported a strong and diffuse staining pattern of CK19 in PTC. Expression of Hector Battifora mesothelial–1 was demonstrated in malignant thyroid neoplasms, especially PTCs.