Vol. 4, Issue 1, Part B (2021)

Abstract: Fluoroquinolones are the quinolone antimicrobials, which are known to have one or more fluorine substitutions. The first generation fluoroquinolones, which was introduced in 1980s have one fluoro substitution. This was very effective in cases of gram-negative bacterias.¹ In the 1990s, compounds with additional fluoro and other substitutions have been developed further extending antimicrobial activity to grampositive cocci and also anaerobes, which also has higher metabolic stability.^2,3,4 The present topic of controversy is tendinopathy and tendon rupture induced by fluoroquinolone. There is enough data, which suggest that fluoroquinolones should be used with utmost care in population of patients.⁵ That means not all the patients with gram-negative infections can be given this antibiotic as it has its own side effects. The first one to publish report was that of a fifty-six-year-old patient who had urinary tract infection and was treated with norfloxacin.