International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology

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International Journal of Clinical and Diagnostic Pathology

2020, Vol. 3 Issue 4, Part APages: 23-26

Evaluation of diagnostic value of nucleated red blood cell count in the early neonatal sepsis

Mahesh Ahirrao, Bhagyashri Ahirrao and Nandkumar Dravid
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ABSTRACT
Objective
1. To Evaluate diagnostic value of Nucleated Red blood cell count in the early diagnosis of neonatal sepsis.
2. To compare and correlate raised Nrbcs with blood culture in diagnosis of neonatal sepsis.
Material and Method: A prospective study was conducted from January2017 to January 2019, in a Tertiary care private Hospital of 120 neonatses neonates with predisposing perinatal risk factors or if there was clinical suspicion of sepsis. Peripheral Blood smears were examined for haematological parameters along with NRBCS count. The data collected was statistically analyzed, to find out the performance of the test individually and in comparison to gold standard that is blood culture under the following parameters. Sensitivity, specificity, positive predictive value and negative predictive value.
Results: Presence of Nrbcs in peripheral smears of culture positive sepsis noted in 82.14% cases. Sensitivity of Nrbcs is 78.57%. Specificity is 89.13%, Positive predictive value 68.75%, Negative predictive value 93.18%.
Conclusion: Nrbcs is a single, quick, cost-effective and readily available, feasible tool with good sensitivity and specificity in the early diagnosis of neonatal sepsis. It gives comparable results to blood culture and can be done even in small hospitals and in peripheral setups, allowing prompt treatment of infected neonates and thereby reducing morbidity and mortality.
How to cite this article:
Mahesh Ahirrao, Bhagyashri Ahirrao and Nandkumar Dravid. Evaluation of diagnostic value of nucleated red blood cell count in the early neonatal sepsis. International Journal of Clinical and Diagnostic Pathology. 2020; 3(4): 23-26. DOI: 10.33545/pathol.2020.v3.i4a.308
International Journal of Clinical and Diagnostic Pathology