Background: The ABH secretors amongst blood groups are known to be associated with some bacterial infections. The prevalence of such secretors and association with incidence of rheumatic fever was studied in south Indian population.
Aims/Objectives: To characterise the association of secretors and non-secretors in ABO Blood group with incidence of Rheumatic fever in south Indian population.
Methodology: An observational study was conducted on 200 subjects, recruited by convenient sampling after meeting the inclusion and exclusion criteria. The procedure involved collection venous blood and unstimulated whole saliva samples, determination of ABO and Rh blood groups (agglutination method), evaluation of the secretor status (Haemagglutination Inhibition Technique) and Antistreptolysin O titre levels. The descriptive statistics were reported as frequencies and percentages while inferential statistics by chi-square or ANOVA test as needed.(p<0.05 were considered significant).
Results: The study consisted male to female ratio of 1:3 with a mean age 18 ±4.65 years. Around 58% (n=116) were found to be secretors and 42% (n=84) were non secretors amongst the ABO groups. Considering the incidence of rheumatic fever, all of the secretors, were proved negative for Rheumatic factor in serum.
Conclusion: The secretors are more prevalent in study population with a higher association with male sex and blood group B. The secretor status of the ABO blood groups had nil association with occurrence of rheumatic fever in the given study population.