International Journal of Clinical and Diagnostic Pathology

The American joint committee on cancer (AJCC) eighth edition staging system integrates clinical laboratory testing for a more comprehensive and personalized prognostic staging criteria^. This study aims to revaluate the clinic pathological character of tumour and prognostic staging system. Retrospective analysis was conducted on patients with invasive breast carcinoma for the period of four years from August 2016 – July 2020, conventional anatomic staging were restaged to prognostic staging. total 77 cases 23 (29.9%) cases stage unchanged, 18 (23.4%) cases Down staged and 36 (46.7%) cases upstaged. 36.5% cases of grade II were down staged, as it is ER, PR positive and Her 2 Neu negative, 90.5% of grade III were upstaged all cases were triple negative. More sample size and survival rate estimation along with present study will provide more insight toward the changes and impact on tumour biology and predictive value of prognostic staging of 8^th edition AJCC.