International Journal of Clinical and Diagnostic Pathology

In order to see a relationship between gleason scores on histopathology and PSA levels, group of 200 men were studied which included obtaining there cumulative Gleason score and serum PSA levels before surgical intervention. Two groups were obtained, 178 cases with high (6-10) and 22 with low (2-5) Gleason score. Mean S.PSA levels in patients with high gleason score was 128ng/ml (normal range 0 to 5) and mean PSA levels for patients with low scores was 25ng/ml. The group with high gleason score showed greater increase in serum PSA levels than lower gleason score.