International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology

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International Journal of Clinical and Diagnostic Pathology

2020, Vol. 3 Issue 1, Part GPages: 428-431

A case of chronic myeloid leukemia with Philadelphia chromosome, BCR-ABL transcript and complex translocation involving four different chromosomes

Dr. Somil Singhal
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ABSTRACT
Such reported cases with the e13a3 transcript showed the Ph chromosome on karyotype analysis. This study reported a rare Ph chromosomepositive CML case with new complex chromosomal aberrations and an e13a3 BCR-ABL transcript that has yet to be established. A four-chromosome translocation involving chromosomal regions 12p11.2, 19q13.3, 9q34.1 and 22q11.2, besides a trisomy 8 and a derivative chromosome 12, were identified using high resolution multicolor banding. Reverse transcription polymerase chain reaction products showed the presence of BCR-ABL fusion transcript e13a3, and this signifies the major BCR breakpoint. The significance of the observed rearrangements and their possible role in the progression of CML was investigated.
How to cite this article:
Dr. Somil Singhal. A case of chronic myeloid leukemia with Philadelphia chromosome, BCR-ABL transcript and complex translocation involving four different chromosomes. International Journal of Clinical and Diagnostic Pathology. 2020; 3(1): 428-431. DOI: 10.33545/pathol.2020.v3.i1g.205
International Journal of Clinical and Diagnostic Pathology