Leprosy is a chronic granulomatous disease. It involves the psychological, socioeconomic dimensions of an individual. Histopathology is considered as an accurate method for diagnosing leprosy. Immunity is largely T-cell mediated, whereas deficiency of T-cells causes lepromatous leprosy. The relative proportion of T and B lymphocytes were studied using CD3 and CD20 immunohistochemistry markers (IHC). A Retrospective, prospective and observational study was carried from August 2016 to July 2019. The cases were divided based on histopathological findings. IHC markers CD3 was used to study T cell whereas CD20 was used to study B-cells. As per Ridley Jopling classification maximum cases belonged to indeterminate forms. Bacillary load of 4+ and above was seen in lepromatous leprosy. CD3 showed strong positivity in all types whereas CD20 showed more focal positive staining for lepromatous leprosy than tuberculoid and indeterminate forms.
How to cite this article:
Dr. Vruksha Shetty, Dr. Manjiri Karandikar, Dr. Sameera Mehta, Dr. Vijeeta Ranadive. Histopathological changes in leprosy and its correlation with IHC markers. Int J Clin Diagn Pathol 2020;3(1):352-357. DOI: 10.33545/pathol.2020.v3.i1f.195