Progesterone receptors in complex and/or atypical endometrial hyperplasia and endometrial adenocarcinoma

Endometrial carcinoma is second most common malignancy of female genital tract with an incidence of 5.9 per 100,000 women in the developing counties. In India the incidence id 4.3 per 100,000 women. Endometrial adenocarcinoma are categorised into type I and type II histological types. Type I endometrial adenocarcinomas comprise of 80% of the cases which results due to unopposed estrogen stimulation. It is associated with lesions like Endometrial Intraepithelial Neoplasia (EIN)/Atypical Hyperplasia. Type I endometrial tumors present with a low tumor grade. Endometrial tumors of type II are also called as non endometrioid tumors. It includes serous, clear cell, mucinous and mixed tumors. These tumors account for approximately 10% of cases. Early stage and well differentiated tumors are primarily progesterone positive. Whereas poorly differentiated tumors and type II endometrial cancers are progesterone positive.