International Journal of Clinical and Diagnostic Pathology

Materials and Methods: Clinical cases labelled as castleman’s disease after excluding all other pathological processes in a tertiary care center. Were evaluated and followed A total of five cases were labelled as castleman’s disease at three different sites.

Results: Out of five cases, four were seen in nodes and one was diagnosed in spleen, four cases were unicentric while one was seen to be multicentric. Each case had a different clinical presentation.one case was labelled as Plasma cell type while the other four were hyaline vascular type with one case showing abundant stroma.

Conclusion: The clinical presentations of these cases is entirely different. Each case needs a thorough work up before labelling it as castleman disease. Some of the cases may rarely show transformation to either lymphoma or sarcoma but in our cases no such thing was noted.