International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology

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International Journal of Clinical and Diagnostic Pathology

2019, Vol. 2 Issue 2, Part FPages: 338-340

Comparative evaluation of efficacy of topical 5% amlexanox oral paste and 0.1% triamcinolone acetonide oral paste in the treatment of oral ulcers

Dr. Rohit Singh, Dr. Supriya Singh, Dr. Aaysha Tabinda Nabi, Dr. Irfanul Huda, Dr. Kumar Anand and Dr. Samar Ali Fara
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ABSTRACT
Background: Recurrent aphthous stomatitis (RAS) is a common condition of the mucosa of oral cavity. The present study was aimed to compare efficacy of triamcinolone acetonide 0.1% and 5% amlexanox in management of recurrent aphthous stomatitis (RAS). Materials & Methods: The present study was conducted on 48 patients with history of recurrent aphthous stomatitis. Patients were divided into 2 groups of 24 each. Group I was prescribed topical application of 0.1% triamcinolone acetonide and groupie was given topical application of 5% amlexanox. Both were to be applied on ulcers three times a day for 5 minutes. Patients were evaluated on 1st day, 4th day and 7th day for pain, size and erythema. Results: Group I had 10 males and 14 females and group II had 12 males and 12 females. The difference was non- significant (P>0.05). The mean VAS score in group I on 1st day was 5.2, in group II was 6.4. On 4th day it was 3.2 in group I and 3.6 in group II. It was 1.4 in group I and 2.0 in group II on 7th day. The difference was significant (P<0.05). The mean size of ulcer on 1st day was 4.3 mm and 4.8 mm in group I and group II respectively. It was 3.4 mm and 3.2 mm on 4th day in group I and group II respectively. It was 2.6 mm and 1.8 mm on 7th day in group I and group II respectively. The difference was non- significant (P>0.05). On 1st day, there was severe erythema seen in both groups. On 7th day, it was mild in both groups. Conclusion: Both 5% amlexanox and 0.1% triamcinolone acetonide found to be effective in reducing size, erythema and pain in cases of aphthous ulcers.
How to cite this article:
Dr. Rohit Singh, Dr. Supriya Singh, Dr. Aaysha Tabinda Nabi, Dr. Irfanul Huda, Dr. Kumar Anand and Dr. Samar Ali Fara. Comparative evaluation of efficacy of topical 5% amlexanox oral paste and 0.1% triamcinolone acetonide oral paste in the treatment of oral ulcers. International Journal of Clinical and Diagnostic Pathology. 2019; 2(2): 338-340. DOI: 10.33545/pathol.2019.v2.i2f.124
International Journal of Clinical and Diagnostic Pathology