Histomorphological spectrum of urothelial tumors according to WHO/ISUP consensus classification (2016): Tertiary care center study
Dr. Dipti Gajjar, Dr. Mansi Faujdar, Dr. Rohit Jain and Dr. Shubha Gupta
Neoplastic urinary bladder lesions are responsible for significant morbidity and mortality throughout the world. The WHO/ISUP consensus classification (2016) for Urothelial tumors reflects an improved understanding and knowledge of the morphological types. The new diagnostic categories will increase the diagnostic reproducibility, clinicopathological correlation and prognostication. The most important criterion for optimal cancer treatment is a correct classification of the tumor.
Aim & Objectives: The aim is to study Histomorphological spectrum of urothelial tumors according to World Health Organization / International Society of Urological Pathology consensus classification (2016) and to determine age and sex distribution of urothelial tumors.
Material & Method: Study included 300 urothelial tumor specimens, conducted over a period 15 months, extending from March 2016 to May 2017. H & E stained sections were examined for morphologic diagnosis of urothelial neoplasm. An attempt was made to classify urothelial neoplasm according to WHO/ISUP consensus classification (2016) by two senior consultants of the department.
Results: Among 300 cases, 14.33% cases were diagnosed as Infiltrating urothelial carcinoma, 85.66% cases were of Non-invasive urothelial neoplasia. Amongst which Non-invasive papillary urothelial carcinoma, low grade were most common that is 55.33% cases. Maximum no. of cases was diagnosed (33%) in 61-70 years of age group and male Female ratio being 3:1.
Conclusion: This study documents a high frequency of non-invasive than infiltrating type of urothelial neoplasm. Non-invasive papillary urothelial carcinoma, low grade constitutes the commonest of urothelial tumors. Urothelial tumors are seen commonly in seventh decade with overall a male predominance.