International Journal of Clinical and Diagnostic Pathology

International Journal of Clinical and Diagnostic Pathology

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International Journal of Clinical and Diagnostic Pathology

2020, Vol. 3 Issue 1, Part DPages: 248-251

Phenotype and kinetics of the endogenous pulmonary CD4 T cell response to a primary influenza: A virus infection

Dr. Poonam Sharma, Dr. Pawan Kumar, Dr. Suman Sharma, Dr. Priyadershini Rangari
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ABSTRACT
Background: Viral and bacterial pneumonias are a leading killer of children and adults worldwide. Influenza A virus (IAV) is one of the most common causes of viral pneumonias, infecting up to 20% of the population each year.
Objectives: To provides insight into the specialized subsets present in the influenza A virus-specific CD4 T cell response in the lungs and demonstrates that this response is regulated by pulmonary antigen presenting cells.
Methods: Female BALB/c and C57Bl/6 mice at 8-12 weeks of age for all experiments were used. Age- and weight-matched groups of female C57Bl/6 mice were lightly anesthetized by isoflurane inhalation and infected intra nasally.
Results: A significant increase in the frequency of CD4 T cells producing IFN╬│ following incubation with peptide-pulsed splenic stimulator DC, compared with CD4 T cells incubated with non-peptide-pulsed splenic stimulator DC.IAV-specific CD4 and CD8 T cells specific for highly conserved epitopes within the internal proteins of IAV can provide hetero subtypic protection. Conclusion: Authors found that IAV and GAS are individually important human pathogens that cause a significant amount of global disease and death. Understanding the immune response to these pathogens is the key to development of better treatments and vaccinations.
How to cite this article:
Dr. Poonam Sharma, Dr. Pawan Kumar, Dr. Suman Sharma, Dr. Priyadershini Rangari. Phenotype and kinetics of the endogenous pulmonary CD4 T cell response to a primary influenza: A virus infection. International Journal of Clinical and Diagnostic Pathology. 2020; 3(1): 248-251. DOI: 10.33545/pathol.2020.v3.i1d.182