Study of immune histo chemical markers in breast cancer and their correlation with various clinico pathological parameters at tertiary care center in Saurashtra region
Dr. Vijay C Popat, Dr. Asha Satwara, Dr. Akshay Panchal and Dr. Hetal Joshi
Breast cancer poses a huge epidemiological burden in Saurashtra region. Breast cancer can be completely treated if diagnosed at an early stage. Hormone receptors (ER and PR) and human epidermal growth factor receptor-2 (HER-2) are the most widely used biomarkers that are used in stratifying breast cancer treatment and management. Predictive factors evaluate the likelihood of benefit from a specific treatment. ER, PR, and HER2/neu are prognostic as well as predictive factors. The present study was conducted to correlate the expression of ER, PR, and HER2/neu with each other and to various clinopathological parameters as follows: age of the patient, histological grade, tumor size, and lymph node metastasis.
Material and Method: The current study was performed at a tertiary care center in Saurashtra region on Eighty One patients diagnosed with breast malignancy. We analyzed the expression of ER, PR, HER2/neu and Ki67 index by immunohistochemistry (IHC), with each other and to various clinico-pathological parameters.
Result: In the present study the maximum number of patients belonged to the age group 41-59 years (61.7%). The most common histological type was Invasive Ductal carcinoma of No Special Type (IDC NST) with more common involvement of left sided breast .Out of total 81 cases, majority of the cases were classified as Luminal A.
Conclusion: In the present study, majority of the patients were having invasive ductal carcinoma, NST type with various patterns of expression of IHC markers. IHC is an easy and economic method for the prognostic classification of various breast cancer where molecular techniques are unavailable. This is valuable in reducing the overall burden of breast cancer in the Saurashtra region.